Stability & Solubility
T-Bec® urea (TBEU) demonstrates exceptional solubility in commonly employed peptide coupling solvents like DMF or NMP, as well as future green/ binary solvents. This reduces the risk of equipment clogging during manufacturing.
The analytical results show that T-Bec® is stable for 12 months if kept in the dark at 2°C to 8°C.
Solubility of tert-butyl ethyl urea ( TBEU) vs. diisopropyl urea (DIU) in various solvents (RT).
| Solvent | Solubility DIU (M) | Solubility TBEU (M) |
| DMF | 0.27 | 0.50 |
| THF | 0.07 | 0.50 |
| 2-MeTHF | 0.38 | 0.50 |
| DMSO/EtOAc (1:1) | 0.23 | 0.50 |
| DMSO/2-MeTHF (1:1) | 0.28 | 0.50 |
| NBP/2-MeTHF (1:1) | 0.16 | 0.50 |
| NBP/EtOAc (1:1) | 0.11 | 0.50 |