tert-Butylethylcarbodiimide as an Efficient Substitute for Diisopropylcarbodiimide in Solid-Phase Peptide Synthesis: Understanding the Side Reaction of Carbodiimides with OxymaPure Srinivasa Rao Manne, Damilola Caleb Akintayo, Omar Luna, Ayman El-Faham, Beatriz G. de la Torre, and Fernando Albericio Organic Process Research & Development 2022 26 (10), 2894-2899 DOI: 10.1021/acs.oprd.2c00220
Amide Formation: Choosing the Safer Carbodiimide in Combination with OxymaPure to Avoid HCN Release Srinivasa Rao Manne, Omar Luna, Gerardo A. Acosta, Miriam Royo, Ayman El-Faham, Gyorgy Orosz, Beatriz G. de la Torre, and Fernando Albericio Organic Letters 2021 23 (17), 6900-6904 DOI: 10.1021/acs.orglett.1c02466
Synthesis of the Antimicrobial Peptide Murepavadin Using Novel Coupling Agents García-Gros, Júlia, Yolanda Cajal, Ana Maria Marqués, and Francesc Rabanal. 2024. Biomolecules 14, no. 5: 526. https://doi.org/10.3390/biom14050526
Solid Phase Peptide Synthesis using side-chain unprotected arginine and histidine, with Oxyma Pure/TBEC in green solvents.T. Fantoni, A. Orlandin, I. Di Stefano, M. Macis, A. Tolomelli, A. Ricci, W. Cabri and L. Ferrazzano, Green Chem, 2024, Accepted Manuscript, DOI: 10.1039/D4GC03209H
Application of a new green protocol in solid-phase peptide synthesis: identification of a new green solvent mixture compatible with TBEC/ETT. Vivenzio, G., Scala, M. C., Auriemma, G., Sardo, C., Campiglia, P., & Sala, M. (2024). https://doi.org/10.1080/17518253.2024.2404234
Elevating 1-tert-Butyl-3-ethylcarbodiimide (TBEC) as a Reagent for Sustainable Peptide Synthesis: Quality Assessment and Minimizing Racemization, Precipitation, and Radical-Induced Side Reactions by TBEC/Oxyma Couplings in an Environmentally Sensible Solvent Jan Pawlas, Ji-Hyung Choi, Christoph von Bargen, Sheila Maibom-Thomsen, Jon H. Rasmussen, and Olivier Ludemann-HombourgerOrganic Process Research & Development 2023 27 (7), 1348-1364 DOI: 10.1021/acs.oprd.3c00120